Who Are We?
Microgenesis is a biotech startup created by women for women, with the goal of helping to find more natural and effective solutions to restore women's fertility potential.
Microgenesis was founded in 2020 by reproductive immunology researchers who spent 15 years studying the impact of systemic inflammation on fertility. Microgenesis' scientific research* and advances in cutting-edge technology provide functional tests and solutions. The Microgenesis test identifies 98 gut flora profiles that trigger immunological changes leading to reproductive conditions and tailors natural solutions that optimize health and fertility.
Microgenesis technology identifies different epigenetic changes in the microbiome that contribute to the development of polycystic ovary syndrome, endometriosis, premature ovarian failure, autoimmunity, recurrent candidiasis and vulvovaginitis. Based on science and the experiences of those who have followed your program, we can guide healthcare professionals and patients to identify and customize natural programs that restore reproductive potential and enhance female wellness based on each woman's unique needs.
Our Science
We discovered the relationship between gut microbiota and fertility.
Our scientific team conducted a clinical study on the importance of women's health and the gut microbiome in recurrent implantation failures. We also concluded that each person's chemistry and microbiome are very complex, completely unique and constantly changing depending on the impact of environmental and dietary factors related to lifestyle and the city where each patient lives.
We studied 287 women with unexplained infertility between the ages of 27 and 52, an average pregnancy rate of 1 and an average parity of 0, and an average of 10 years trying to conceive. Before being studied, they underwent an average of 4 IVF cycles, half of them with donor oocytes. We found 3 types of dysbiosis of the intestinal and vaginal microbiome in 80% of them compared to a control group of fertile women. After studying inflammatory markers associated with miRNAs secreted by immune cells in response to the absent microorganisms, we established different microgenesis profiles associated with infertility.
How does it work?
Our technology identifies personalized miRNA signatures that immune cells produce in response to components of the microbiota and travel from the gut to the reproductive tract, affecting immunometabolic pathways and triggering systemic, ovarian and endometrial inflammation.
These miRNAs affect fertility through inflammatory processes and can be analyzed using a vaginal sample obtained with a non-invasive swab.
We found that the gut microbiota of women with unexplained infertility is different from that of fertile women. These changes are associated with a subclinical inflammatory process that could have an impact on the pregnancy rate.
The microorganisms in our microbiota are responsible for metabolizing nutrients and act as a protective barrier. When the microbiota is altered, it affects metabolic immune responses. A weakened immune system can cause systemic inflammation, which makes pregnancy difficult and can lead to miscarriages.
What happens if the intestinal microbiota is altered?
Leaky gut syndrome is a disease that occurs when the intestinal microbiota is altered. This makes the junction between the cells of the intestinal barrier more lax, allowing toxins, bacteria and other substances that should not cross this barrier to reach the blood. This causes inflammation and systemic weakening of the immune system. Symptoms can include fatigue, acne, eczema, constipation, mental health problems, problems in the proper assimilation of nutrients, infertility, among others. There are studies that link intestinal dysbiosis with diseases such as endometriosis and thyroid autoimmunity.
Intestinal dysbiosis is associated with insulin resistance as a survival strategy that is essential during fasting and in the fight against infections. The relationship with some components of the diet and, in particular, with the gut microbiota points to new paradigms in the understanding of the pathophysiology of polycystic ovary and metabolic syndrome.
MICROGENESIS Fertility Program
The Fertility program is designed to optimize the reproductive potential in four fundamental steps.
First, assertive testing and diagnosis will provide with an accurate assessment of the current reproductive health, identifying specific areas that could affect the reproductive potential.
Next, through supplementation with customized nutraceuticals and probiotics, we will strengthen the reproductive system by addressing the root cause and improving the quality and vitality of the key biological processes for fertility.
The Complementary Eating Plan will guide you toward strategic nutrition, offering specific recipes and guidelines designed to enhance reproductive health.
Finally, Personalized Physical Activity will focus on specific exercises that promote fertility and enhance overall wellness.
WHAT IS INCLUDED
ā¶ 1 Test kit and how to collect the sample video and return label to send the samples.
ā¶ 1 Report explaining which of the 98 microbiota profiles each patient belongs to and what the clinical impact is.
ā¶ Online report outlining a personal restoration program for 75 days.
ā¶ Video explaining your profile and what it means and how to proceed with restoration
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WHAT IS NOT INCLUDED
ā¶ Dietary supplement that are in the Restoration Report (Probiotics and Nutraceuticals).
ā¶ Individual coaching sessions are available a reasonable cost
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Fertility Coaching via video Conference
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Nutritional Coaching via video Conference
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Emotional Coaching via video Conference
ā¶ Fitness training video packages according to profile.
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